Z36 ≥98% (HPLC) Sigma SML0176
По запросу
Наличие: Срок поставки 60 дней
- Производитель: Sigma
- Каталожный номер:
SML0176 - CAS номер :
Application
Z36 may be used to study cell signaling that results in autophagy.
Biochem/physiol Actions
Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.1
Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1.
Характеристики реактива | |
assay | ≥98% (HPLC) |
Molecular Formula | C23H24FN3O2 |
storage temp. | −20°C |