Withaferin A ≥95% (HPLC) Sigma W4394
По запросу
- Производитель: Sigma
- Каталожный номер:
W4394 - CAS номер : 5119-48-2
Frequently Asked Questions
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Biochem/physiol Actions
Steroidal lactone that exhibits cytotoxicity towards tumor cells. Protective effects attributed to anti-lipid peroxidative, antioxidant and detoxifying functionality.
Withaferin A is a steroidal lactone that is isolated from the plant Withania somnifera. It has potent anti-inflammatory properties as it inhibits the activation of NF-κ B signaling pathway.2 The anti-tumor activity of Withaferin A is due to its ability to alter cytoskeletal architecture by binding annexin II and disrupting F actin cross-links.3 Withaferin A also inhibits angiogenesis by binding to vimentin and F-actin.4
Preparation Note
Withaferin A yields a clear, colorless solution in methanol at 1 mg/ml.
Application
Withaferin A was used to treat HEK293 cells to study its effect on cystic fibrosis inflammation.1
Характеристики реактива | |
assay | ≥95% (HPLC) |
Molecular Formula | C28H38O6 |
storage temp. | 2-8°C |