[Phenylacetyl1, O-Me-D -Tyr2, Arg6,8, Lys9]-Vasopressin amide >98% (HPLC), solid Sigma V2138
Amino Acid Sequence
Phenylac-MeTyr-Phe-Gln-As
Biochem/physiol Actions
Selective antagonist having an extremely high affinity for the V-1a vasopressin receptors.
Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide is a selective antagonist with high affinity for the V-1a vasopressin receptors. Vasopressin can stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.2It can also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.3 Additionally, it can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.4
Preparation Note
Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide dissolves in water at 1 mg/ml.
Application
Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide was used as a test compound to study the effects of hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) on reduce humoral immune responses of rats.1
Характеристики реактива | |
assay | >98% (HPLC) |
Molecular Formula | C59H86N18O12 |
storage temp. | −20°C |