Xanthine Oxidase from bovine milk Grade IV, ammonium sulfate suspension, 0.1-0.4 units/mg protein Sigma X4875
По запросу
- Производитель: Sigma
- Каталожный номер:
X4875 - CAS номер : 9002-17-9
Analysis Note
Protein determined by biuret
General description
Formerly E.C. 1.1.3.22
Unit Definition
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
Physical form
Suspension in 2.3 M (NH4)2SO4 containing 1 mM sodium salicylate
Biochem/physiol Actions
Although xanthine oxidase is found widely distributed in multiple tissues, it is highly expressed in endothelial and epithelial cells. Its expression was also increased in infected tissues where it was shown to have an anti-microbial effect due to its ability to generate reactive oxygen species. 1
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.
Характеристики реактива | |
storage temp. | 2-8°C |