Vinblastine sulfate salt powder, ≥96% (HPLC) Sigma V1377
По запросу
- Производитель: Sigma
- Каталожный номер:
V1377 - CAS номер : 143-67-9
Biochem/physiol Actions
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.
Features and Benefits
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Legal Information
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Характеристики реактива | |
assay | ≥96% (HPLC) |
Molecular Formula | C46H58N4O9 · H2SO4 |
storage temp. | 2-8°C |