Hemin BioXtra, from Porcine, ≥97.0% (HPLC) Sigma 51280
По запросу
- Производитель: Sigma
- Каталожный номер:
51280 - CAS номер : 16009-13-5
Frequently Asked Questions
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Application
Hemin is used for the following applications:
• To study bacterial strains and growth conditions1
• Used in short-term colony assays (the culture medium consists of hemin along with other components)2
• Cell transfections3
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.4
Biochem/physiol Actions
Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.
Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.
Характеристики реактива | |
assay | ≥97.0% (HPLC) |
Molecular Formula | C34H32ClFeN4O4 |
storage temp. | 2-8°C |