(−)-Thalidomide >98%, solid Sigma T150
По запросу
- Производитель: Sigma
- Каталожный номер:
T150 - CAS номер : 841-67-8
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α); inhibitor of angiogenesis. (S)-Thalidomide is a teratogenic enatiomer.
Packaging
10 mg in poly bottle
25, 100 mg in glass bottle
Preparation Note
(-)-Thalidomide is soluble in DMSO, but is insoluble in water and ethanol.
Application
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis1. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos2.
Features and Benefits
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Характеристики реактива | |
assay | >98% |
Molecular Formula | C13H10N2O4 |