Sulindac ≥98.0% Sigma S8139
По запросу
- Производитель: Sigma
- Каталожный номер:
S8139 - CAS номер : 38194-50-2
Biochem/physiol Actions
Nonsteroidal anti-inflammatory; preferential inhibitor of COX-1.
Sulindac is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells25,26 and reduces tumor burden in adenomatous polyposis patients.27
Packaging
5, 25 g in poly bottle
Application
Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. Sulindac was tested for its effect on heat-induced denaturation of albumin in vitro28 and its ability to bind to human plasma protein.29
Features and Benefits
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Legal Information
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Характеристики реактива | |
assay | ≥98.0% |
Molecular Formula | C20H17FO3S |